منابع مشابه
Antiangiogenic Activity of 2-Deoxy-D-Glucose
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
متن کامل2-Deoxy-2-fluoro-d-glucose metabolism in Arabidopsis thaliana
2-Deoxy-2-fluoro-d-glucose (FDG) is glucose analog routinely used in clinical and animal radiotracer studies to trace glucose uptake but it has rarely been used in plants. Previous studies analyzed FDG translocation and distribution pattern in plants and proposed that FDG could be used as a tracer for photoassimilates in plants. Elucidating FDG metabolism in plants is a crucial aspect for estab...
متن کاملAnticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...
متن کاملThe effect of 2-deoxy-d-glucose and 3-O-methyl-d-glucose on mucosubstance secretion in cell culture.
Ouabain at lm inhibits the secretion of hyaluronic acid by Rous-sarcoma-virustransformed hamster fibroblasts in 5.5 m-glucose medium, but not in glucose-free medium (Duguid & Marsden, 1972). As the amount of secretion in glucose-free medium is 90-95 % of that in glucose-containing medium, it appears that a complex relationship exists between mucosubstance secretion, ion transport and glucose me...
متن کاملEffect of regional hyperemia on myocardial uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose.
2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) may be used to predict glucose kinetics when the factor relating differences in transport and phosphorylation between compounds remains constant ("lumped constant"). It is not clear whether hyperemia alters that factor. In anesthetized swine, myocardial FDG uptake was estimated by positron emission tomography, during an intracoronary infusion of either ad...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1973
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)33128-2